Ontology highlight
ABSTRACT:
SUBMITTER: Feldman KS
PROVIDER: S-EPMC2084345 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Feldman Ken S KS Hester D Keith DK Golbeck John H JH
Bioorganic & medicinal chemistry letters 20070614 17
A series of 11 simple phylloquinone derivatives, each lacking the extended phytyl side chain but featuring H-bond donor amides at one or both peri positions, were prepared and some salient physical properties were measured. A correlation between both IR frequency and NMR peak position, as indicators of internal H-bond strength, and the quinone half-wave reduction potential, was observed. These data are consistent with the prevailing hypothesis that quinone carbonyl H-bonding in general, and stro ...[more]