Unknown

Dataset Information

0

The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.

ABSTRACT: Frequent allelic loss at human chromosome 11q23-q24 occurs in a wide variety of cancers, suggesting that this region may harbor a tumor suppressor gene. By constructing a physical map of the LOH11CR2 minimal region of loss on 11q23-q24 associated with lung and breast carcinomas, we were able to clone a hereditary translocation, t(11;12)(q23;q24), in a patient with early-onset breast cancer and family history of cancer. The breakpoint was found within 6 kb of the BCSC-1 candidate tumor suppressor gene located in the LOH11CR2 region whereas additional loss of heterozygosity (LOH) analysis in breast and ovarian tumors, including that of the patient with the t(11;12)(q23;q24), implicated the BCSC-1 locus as the primary target of deletion. Northern analysis of the BCSC-1 mRNA revealed a lack of expression in 33 of 41 (80%) tumor cell lines, and its ectopic expression led to the suppression of colony formation in vitro and tumorigenicity in vivo. These data suggest that BCSC-1 may exert a tumor suppressor activity and is a likely target of the LOH observed on 11q23-q24 in cancer.

SUBMITTER: Martin ES 

PROVIDER: S-EPMC208790 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.

Martin Eric S ES   Cesari Rossano R   Pentimalli Francesca F   Yoder Kristine K   Fishel Richard R   Himelstein Andrew L AL   Martin S Eric SE   Godwin Andrew K AK   Negrini Massimo M   Croce Carlo M CM  

Proceedings of the National Academy of Sciences of the United States of America 20030922 20

Frequent allelic loss at human chromosome 11q23-q24 occurs in a wide variety of cancers, suggesting that this region may harbor a tumor suppressor gene. By constructing a physical map of the LOH11CR2 minimal region of loss on 11q23-q24 associated with lung and breast carcinomas, we were able to clone a hereditary translocation, t(11;12)(q23;q24), in a patient with early-onset breast cancer and family history of cancer. The breakpoint was found within 6 kb of the BCSC-1 candidate tumor suppressor  ...[more]

Similar Datasets

Unknown Autozygosity mapping of a seckel syndrome locus to chromosome 3q22. 1-q24.
| S-EPMC1287195 | biostudies-literature
Unknown The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis.
| S-EPMC34698 | biostudies-literature
Unknown LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer.
| S-EPMC2844776 | biostudies-other
Unknown Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.
| S-EPMC156308 | biostudies-literature
Unknown MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.
| S-EPMC129434 | biostudies-literature
Unknown Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer.
| S-EPMC1348006 | biostudies-literature
Unknown WWOX: a candidate tumor suppressor gene involved in multiple tumor types.
| S-EPMC58744 | biostudies-literature
Unknown The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11.
| S-EPMC8791575 | biostudies-literature
Unknown Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma.
| S-EPMC2732794 | biostudies-literature
Unknown CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression.
| S-EPMC3131958 | biostudies-literature