Ontology highlight
ABSTRACT:
SUBMITTER: Wulff P
PROVIDER: S-EPMC2092503 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Wulff Peer P Goetz Thomas T Leppä Elli E Linden Anni-Maija AM Renzi Massimiliano M Swinny Jerome D JD Vekovischeva Olga Y OY Sieghart Werner W Somogyi Peter P Korpi Esa R ER Farrant Mark M Wisden William W
Nature neuroscience 20070617 7
In mammals, identifying the contribution of specific neurons or networks to behavior is a key challenge. Here we describe an approach that facilitates this process by enabling the rapid modulation of synaptic inhibition in defined cell populations. Binding of zolpidem, a systemically active allosteric modulator that enhances the function of the GABAA receptor, requires a phenylalanine residue (Phe77) in the gamma2 subunit. Mice in which this residue is changed to isoleucine are insensitive to zo ...[more]