Ontology highlight
ABSTRACT:
SUBMITTER: Pavithra L
PROVIDER: S-EPMC2094063 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Pavithra Lakshminarasimhan L Rampalli Shravanti S Sinha Surajit S Sreenath Kadreppa K Pestell Richard G RG Chattopadhyay Samit S
Nucleic acids research 20070828 18
Prostaglandins are anticancer agents known to inhibit tumor cell proliferation both in vitro and in vivo by affecting the mRNA stability. Here we report that a MAR-binding protein SMAR1 is a target of Prostaglandin A2 (PGA2) induced growth arrest. We identify a regulatory mechanism leading to stabilization of SMAR1 transcript. Our results show that a minor stem and loop structure present in the 5' UTR of SMAR1 (1-UTR) is critical for nucleoprotein complex formation that leads to SMAR1 stabilizat ...[more]