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Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration.


ABSTRACT: We applied optimised voxel based morphometry (VBM) to brain MRIs from autopsy proven cases of tau positive frontotemporal lobar degeneration (FTLD-T, n = 6), ubiquitin and TDP-43 positive/tau negative FTLD (FTLD-U, n = 8) and cognitively normal controls (n = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo.

SUBMITTER: Kim EJ 

PROVIDER: S-EPMC2095621 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature

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Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration.

Kim E J EJ   Rabinovici G D GD   Seeley W W WW   Halabi C C   Shu H H   Weiner M W MW   DeArmond S J SJ   Trojanowski J Q JQ   Gorno-Tempini M L ML   Miller B L BL   Rosen H J HJ  

Journal of neurology, neurosurgery, and psychiatry 20070705 12


We applied optimised voxel based morphometry (VBM) to brain MRIs from autopsy proven cases of tau positive frontotemporal lobar degeneration (FTLD-T, n = 6), ubiquitin and TDP-43 positive/tau negative FTLD (FTLD-U, n = 8) and cognitively normal controls (n = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region of interest tracing of caudate and putamen volumes confirmed the VBM finding  ...[more]

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