Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration.

ABSTRACT: We applied optimised voxel based morphometry (VBM) to brain MRIs from autopsy proven cases of tau positive frontotemporal lobar degeneration (FTLD-T, n = 6), ubiquitin and TDP-43 positive/tau negative FTLD (FTLD-U, n = 8) and cognitively normal controls (n = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo.

SUBMITTER: Kim EJ 

PROVIDER: S-EPMC2095621 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature