Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution.

ABSTRACT: Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K(+) solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understandi

SUBMITTER: Phan AT 

PROVIDER: S-EPMC2095816 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature