Ontology highlight
ABSTRACT:
SUBMITTER: Davies OR
PROVIDER: S-EPMC2096194 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Davies Owen Richard OR Pellegrini Luca L
Nature structural & molecular biology 20070601 6
BRCA2 has an essential function in DNA repair by homologous recombination, interacting with RAD51 via short motifs in the middle and at the C terminus of BRCA2. Here, we report that a conserved 36-residue sequence of human BRCA2 encoded by exon 27 (BRCA2Exon27) interacts with RAD51 through the specific recognition of oligomerized RAD51 ATPase domains. BRCA2Exon27 binding stabilizes the RAD51 nucleoprotein filament against disassembly by BRC repeat 4. The protection is specific for RAD51 filament ...[more]