Ontology highlight
ABSTRACT:
SUBMITTER: Aiyar SE
PROVIDER: S-EPMC2096739 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Aiyar Sarah E SE Cho HyungJun H Lee Jae J Li Rong R
International journal of biological sciences 20071126 7
Cofactor of BRCA1 (COBRA1) was first identified as a protein that binds to the breast cancer susceptibility gene product BRCA1. COBRA1 modulates estrogen-dependent and independent transcription and suppresses the growth of breast cancer cells. Its expression is significantly reduced in metastatic and recurrent breast cancer, pointing to a tumor suppressor function in breast cancer development. In light of these initial implications of COBRA1 in human breast cancer, the current investigation soug ...[more]