Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC2099463 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Lu Yuan Y Allen Margaret M Halt Amy R AR Weisenhaus Michael M Dallapiazza Robert F RF Hall Duane D DD Usachev Yuriy M YM McKnight G Stanley GS Hell Johannes W JW
The EMBO journal 20071101 23
Association of PKA with the AMPA receptor GluR1 subunit via the A kinase anchor protein AKAP150 is crucial for GluR1 phosphorylation. Mutating the AKAP150 gene to specifically prevent PKA binding reduced PKA within postsynaptic densities (>70%). It abolished hippocampal LTP in 7-12 but not 4-week-old mice. Inhibitors of PKA and of GluR2-lacking AMPA receptors blocked single tetanus LTP in hippocampal slices of 8 but not 4-week-old WT mice. Inhibitors of GluR2-lacking AMPA receptors also prevente ...[more]