Ontology highlight
ABSTRACT:
SUBMITTER: Lee CH
PROVIDER: S-EPMC2099465 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Lee Chung-Han CH Inoki Ken K Karbowniczek Magdalena M Petroulakis Emmanuel E Sonenberg Nahum N Henske Elizabeth Petri EP Guan Kun-Liang KL
The EMBO journal 20071025 23
Miscoordination of growth and proliferation with the cellular stress response can lead to tumorigenesis. Mammalian target of rapamycin (mTOR), a central cell growth controller, is highly activated in some malignant neoplasms, and its clinical implications are under extensive investigation. We show that constitutive mTOR activity amplifies p53 activation, in vitro and in vivo, by stimulating p53 translation. Thus, loss of TSC1 or TSC2, the negative regulators of mTOR, results in dramatic accumula ...[more]