Ontology highlight
ABSTRACT:
SUBMITTER: Dabir DV
PROVIDER: S-EPMC2099471 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Dabir Deepa V DV Leverich Edward P EP Kim Sung-Kun SK Tsai Frederick D FD Hirasawa Masakazu M Knaff David B DB Koehler Carla M CM
The EMBO journal 20071101 23
Erv1 is a flavin-dependent sulfhydryl oxidase in the mitochondrial intermembrane space (IMS) that functions in the import of cysteine-rich proteins. Redox titrations of recombinant Erv1 showed that it contains three distinct couples with midpoint potentials of -320, -215, and -150 mV. Like all redox-active enzymes, Erv1 requires one or more electron acceptors. We have generated strains with erv1 conditional alleles and employed biochemical and genetic strategies to facilitate identifying redox p ...[more]