Dataset Information

A case-control study of presentations in general practice before diagnosis of coeliac disease.

ABSTRACT:

Background

Delay in the diagnosis of coeliac disease prolongs morbidity and may increase mortality. Little is known about presentations in general practice that may predict a subsequent diagnosis of coeliac disease.

Aim

To examine presentations in general practice during the 5 years prior to diagnosis of coeliac disease.

Design of study

A case-control study with each biopsy-proven coeliac disease case matched by age, sex, and general practice to an average of two controls.

Setting

Thirty-seven general practices in south-east Wales.

Method

Cases were identified via a secondary care clinic and controls recruited from the general practices of cases. General practice clinical records of both cases and controls were analysed to determine frequency of consultations, presenting symptoms, diagnoses, referrals, and investigations during the 5 years prior to diagnosis.

Results

Cases (n = 68) had an increased number of consultations compared with controls (n = 160) during the 5 years prior to diagnosis (mean difference five consultations, P = 0.001). Three clinical features were independently associated with subsequent diagnosis of coeliac disease: depression and/or anxiety (odds ratio [OR] = 2.5, 95% confidence interval [CI] = 1.1 to 5.7, P = 0.031); diarrhoea (OR = 4.5, 95% CI = 2.0 to 10.0, P <0.001); and anaemia (OR = 26.3, 95% CI = 5.7 to 120.6, P <0.001). Both diarrhoea and anaemia remained associated even when data for the year prior to diagnosis was excluded from the analysis.

Conclusion

[corrected] GPs should consider testing for coeliac disease when patients present often, especially with diarrhoea and/or who are discovered to be anaemic. Further research is required to clarify the role of depression and/or anxiety in the diagnosis of coeliac disease.

SUBMITTER: Cannings-John R

PROVIDER: S-EPMC2099669 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

A case-control study of presentations in general practice before diagnosis of coeliac disease.

Cannings-John Rebecca R Butler Christopher C CC Prout Hayley H Owen Diane D Williams Della D Hood Kerenza K Crimmins Rosemary R Swift Gillian G

The British journal of general practice : the journal of the Royal College of General Practitioners 20070801 541

<h4>Background</h4>Delay in the diagnosis of coeliac disease prolongs morbidity and may increase mortality. Little is known about presentations in general practice that may predict a subsequent diagnosis of coeliac disease.<h4>Aim</h4>To examine presentations in general practice during the 5 years prior to diagnosis of coeliac disease.<h4>Design of study</h4>A case-control study with each biopsy-proven coeliac disease case matched by age, sex, and general practice to an average of two controls.< ...[more]

PMID: 17688758

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Dataset Information

A case-control study of presentations in general practice before diagnosis of coeliac disease.

Background

Aim

Design of study

Setting

Method

Results

Conclusion

Publications

A case-control study of presentations in general practice before diagnosis of coeliac disease.

Similar Datasets

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