Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-beta1 gene.

ABSTRACT:

Background

Liver fibrosis represents a significant and severe health care problem and there are no efficient drugs for therapy so far. Preventing the progression of fibrogenesis and revival endogenous repair activities is an important strategy for both current and future therapies. Many studies of liver fibrosis consist of animal testing with various hepatotoxins. Although this method is often used, the model at which cirrhosis or extensive fibrosis becomes irreversible has not been well defined and is not representative of early-stage fibrogenesis. We here report the establishment of a transient and reversible liver fibrosis animal model which may better represent an early and natural fibrotic event. We used a high-speed intravenous injection of naked plasmid DNA of transforming g

SUBMITTER: Yang KL 

PROVIDER: S-EPMC2104536 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature