Clustered gene expression changes flank targeted gene loci in knockout mice.
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ABSTRACT:
SUBMITTER: Valor LM
PROVIDER: S-EPMC2110885 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Publications
Clustered gene expression changes flank targeted gene loci in knockout mice.
Valor Luis M LM Grant Seth G N SG
PloS one 20071212 12
<h4>Background</h4>Gene expression profiling using microarrays is a powerful technology widely used to study regulatory networks. Profiling of mRNA levels in mutant organisms has the potential to identify genes regulated by the mutated protein.<h4>Methodology/principle findings</h4>Using tissues from multiple lines of knockout mice we have examined genome-wide changes in gene expression. We report that a significant proportion of changed genes were found near the targeted gene.<h4>Conclusions/si ...[more]
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