Ontology highlight
ABSTRACT:
SUBMITTER: Varrault A
PROVIDER: S-EPMC21163 | biostudies-literature | 1998 Jul
REPOSITORIES: biostudies-literature
Varrault A A Ciani E E Apiou F F Bilanges B B Bilanges B B Hoffmann A A Pantaloni C C Bockaert J J Spengler D D Journot L L
Proceedings of the National Academy of Sciences of the United States of America 19980701 15
We previously reported the identification of mZac, a novel mouse zinc finger protein that shared with p53 the ability to regulate concomitantly apoptosis and cell cycle progression. We describe here the isolation, chromosomal localization, and functional in vitro characterization of its human homolog. hZAC is a widely expressed zinc finger protein that reveals transactivation and DNA-binding activity. hZAC inhibits tumor cell growth through induction of apoptotic cell death and G1 arrest. Thus h ...[more]