Dataset Information

A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry.

ABSTRACT:

Background

Dementia is common in Parkinson's disease, but the underlying brain pathology is not yet fully understood.

Aim

To examine the changes in the brain of patients with Parkinson's disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging.

Methods

Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson's disease and dementia (PDD; n = 16) and Parkinson's disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used.

Results

Widespread areas of cortical atrophy were found in patients with PDD compared with normal controls (in both temporal and frontal lobes and in the left parietal lobe). Grey matter reductions were found in frontal, parietal, limbic and temporal lobes in patients with PDD compared with those with PDND. In patients with PDND with MCI, areas of reduced grey matter in the left frontal and both temporal lobes were found.

Conclusion

These findings show that dementia in Parkinson's disease is associated with structural neocortical changes in the brain, and that cognitive impairment in patients with PDND may be associated with structural changes in the brain. Further studies with larger groups of patients are needed to confirm these findings.

SUBMITTER: Beyer MK

PROVIDER: S-EPMC2117633 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

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Publications

A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry.

Beyer Mona K MK Janvin Carmen C CC Larsen Jan P JP Aarsland Dag D

Journal of neurology, neurosurgery, and psychiatry 20061006 3

<h4>Background</h4>Dementia is common in Parkinson's disease, but the underlying brain pathology is not yet fully understood.<h4>Aim</h4>To examine the changes in the brain of patients with Parkinson's disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging.<h4>Methods</h4>Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson's disease and dementia (PDD; n = 16) and Parkinson's disease without dementia (PD ...[more]

PMID: 17028119

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Dataset Information

A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry.

Background

Aim

Methods

Results

Conclusion

Publications

A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry.

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