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Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?

ABSTRACT: Sensory involvement is thought not to be a feature of amyotrophic lateral sclerosis (ALS). However, in the setting of a specialist motor neuron disease clinic, we have identified five patients with sporadic ALS and a sensory neuropathy for which an alternative cause could not be identified. In three individuals, sensory nerve biopsy was performed, demonstrating axonal loss without features of an alternative aetiology. These findings support the hypothesis that ALS is a multisystem neurodegenerative disorder that may occasionally include sensory neuropathy among its non-motor features.

SUBMITTER: Isaacs JD

PROVIDER: S-EPMC2117693 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature

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Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?

Isaacs Jeremy D JD Dean Andrew F AF Shaw Christopher E CE Al-Chalabi Ammar A Mills Kerry R KR Leigh P Nigel PN

Journal of neurology, neurosurgery, and psychiatry 20070701 7

Sensory involvement is thought not to be a feature of amyotrophic lateral sclerosis (ALS). However, in the setting of a specialist motor neuron disease clinic, we have identified five patients with sporadic ALS and a sensory neuropathy for which an alternative cause could not be identified. In three individuals, sensory nerve biopsy was performed, demonstrating axonal loss without features of an alternative aetiology. These findings support the hypothesis that ALS is a multisystem neurodegenerat ...[more]

PMID: 17575021

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