Ontology highlight
ABSTRACT:
SUBMITTER: Sokurenko EV
PROVIDER: S-EPMC21178 | biostudies-literature | 1998 Jul
REPOSITORIES: biostudies-literature
Sokurenko E V EV Chesnokova V V Dykhuizen D E DE Ofek I I Wu X R XR Krogfelt K A KA Struve C C Schembri M A MA Hasty D L DL
Proceedings of the National Academy of Sciences of the United States of America 19980701 15
Conventional wisdom regarding mechanisms of bacterial pathogenesis holds that pathogens arise by external acquisition of distinct virulence factors, whereas determinants shared by pathogens and commensals are considered to be functionally equivalent and have been ignored as genes that could become adapted specifically for virulence. It is shown here, however, that genetic variation in an originally commensal trait, the FimH lectin of type 1 fimbriae, can change the tropism of Escherichia coli, s ...[more]