BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism.
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ABSTRACT:
SUBMITTER: Patke A
PROVIDER: S-EPMC2118121 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Publications
BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism.
Patke Alina A Mecklenbräuker Ingrid I Erdjument-Bromage Hediye H Tempst Paul P Tarakhovsky Alexander A
The Journal of experimental medicine 20061023 11
B cell life depends critically on the cytokine B cell-activating factor of the tumor necrosis factor family (BAFF). Lack of BAFF signaling leads to B cell death and immunodeficiency. Excessive BAFF signaling promotes lupus-like autoimmunity. Despite the great importance of BAFF to B cell biology, its signaling mechanism is not well characterized. We show that BAFF initiates signaling and transcriptional programs, which support B cell survival, metabolic fitness, and readiness for antigen-induced ...[more]
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