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Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.


ABSTRACT: The ataxia telangiectasia mutated (ATM) kinase is a key tumor suppressor that regulates numerous cell cycle checkpoints as well as apoptosis. Here, we report that ATM is a critical player in the regulation of apoptosis and lymphomagenesis in the presence of c-myc. In turn, deletion of the inhibitory ATM phosphatase, Wip1, results in ATM up-regulation and suppression of Emicro-myc-induced B cell lymphomas. Using mouse genetic crosses, we show that the onset of myc-induced lymphomas is dramatically delayed in Wip1-null mice in an ATM- and p53-, but not p38 MAPK- or Arf-, dependent manner. We propose that Wip1 phosphatase is critical for regulating the ATM-mediated tumor surveillance network.

SUBMITTER: Shreeram S 

PROVIDER: S-EPMC2118180 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature

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Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.

Shreeram Sathyavageeswaran S   Hee Weng Kee WK   Demidov Oleg N ON   Kek Calvina C   Yamaguchi Hiroshi H   Fornace Albert J AJ   Anderson Carl W CW   Appella Ettore E   Bulavin Dmitry V DV  

The Journal of experimental medicine 20061211 13


The ataxia telangiectasia mutated (ATM) kinase is a key tumor suppressor that regulates numerous cell cycle checkpoints as well as apoptosis. Here, we report that ATM is a critical player in the regulation of apoptosis and lymphomagenesis in the presence of c-myc. In turn, deletion of the inhibitory ATM phosphatase, Wip1, results in ATM up-regulation and suppression of Emicro-myc-induced B cell lymphomas. Using mouse genetic crosses, we show that the onset of myc-induced lymphomas is dramaticall  ...[more]

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