Systemic antithrombotic effects of ADAMTS13.
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ABSTRACT:
SUBMITTER: Chauhan AK
PROVIDER: S-EPMC2118248 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Publications
Systemic antithrombotic effects of ADAMTS13.
Chauhan Anil K AK Motto David G DG Lamb Colin B CB Bergmeier Wolfgang W Dockal Michael M Plaimauer Barbara B Scheiflinger Friedrich F Ginsburg David D Wagner Denisa D DD
The Journal of experimental medicine 20060313 3
The metalloprotease ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type I repeats 13) cleaves highly adhesive large von Willebrand factor (VWF) multimers after their release from the endothelium. ADAMTS13 deficiency is linked to a life-threatening disorder, thrombotic thrombocytopenic purpura (TTP), characterized by platelet-rich thrombi in the microvasculature. Here, we show spontaneous thrombus formation in activated microvenules of Adamts13-/- mice by intravital microsco ...[more]
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