Ontology highlight
ABSTRACT:
SUBMITTER: Hanada T
PROVIDER: S-EPMC2118311 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Hanada Toshikatsu T Kobayashi Takashi T Chinen Takatoshi T Saeki Kazuko K Takaki Hiromi H Koga Keiko K Minoda Yasumasa Y Sanada Takahito T Yoshioka Tomoko T Mimata Hiromitsu H Kato Seiya S Yoshimura Akihiko A
The Journal of experimental medicine 20060522 6
Approximately 20% of human cancers are estimated to develop from chronic inflammation. Recently, the NF-kappaB pathway was shown to play an essential role in promoting inflammation-associated cancer, but the role of the JAK/STAT pathway, another important signaling pathway of proinflammatory cytokines, remains to be investigated. Suppressor of cytokine signaling-1 (SOCS1) acts as an important physiological regulator of cytokine responses, and silencing of the SOCS1 gene by DNA methylation has be ...[more]