Ontology highlight
ABSTRACT:
SUBMITTER: Boyman O
PROVIDER: S-EPMC2118360 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Boyman Onur O Cho Jae-Ho JH Tan Joyce T JT Surh Charles D CD Sprent Jonathan J
The Journal of experimental medicine 20060703 7
Most memory phenotype (MP) CD44(hi) CD8(+) cells are resting interleukin (IL)-15-dependent cells characterized by high expression of the IL-2/IL-15 receptor beta (CD122). However, some MP CD8(+) cells have a CD122(lo) phenotype and are IL-15 independent. Here, evidence is presented that the CD122(lo) subset of MP CD8(+) cells is controlled largely by major histocompatibility complex (MHC) class I molecules. Many of these cells display surface markers typical of recently activated T cells (CD62L( ...[more]