Ontology highlight
ABSTRACT:
SUBMITTER: Prosser BE
PROVIDER: S-EPMC2118454 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Prosser Beverly E BE Johnson Steven S Roversi Pietro P Herbert Andrew P AP Blaum Bärbel S BS Tyrrell Jess J Jowitt Thomas A TA Clark Simon J SJ Clark Simon J SJ Tarelli Edward E Uhrín Dusan D Barlow Paul N PN Sim Robert B RB Day Anthony J AJ Lea Susan M SM
The Journal of experimental medicine 20070924 10
Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His substitution at position 402, is linked to approximately 50% of attributable risks for AMD. We present the crystal structure of the region of FH containing the polymorphic amino acid His402 in complex with an analogue of the glycosaminoglycans (GAGs) tha ...[more]