Ontology highlight
ABSTRACT:
SUBMITTER: Andzelm MM
PROVIDER: S-EPMC2118468 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Andzelm Milena M MM Chen Xi X Krzewski Konrad K Orange Jordan S JS Strominger Jack L JL
The Journal of experimental medicine 20070917 10
Natural killer (NK) cell cytotoxicity involves the formation of an activating immunological synapse (IS) between the effector and target cell through which granzymes and perforin contained in lytic granules are delivered to the target cell via exocytosis. Inhibition of nonmuscle myosin II in human NK cells with blebbistatin or ML-9 impaired neither effector-target cell conjugation nor formation of a mature activating NK cell IS (NKIS; formation of an actin ring and polarization of the microtubul ...[more]