Ontology highlight
ABSTRACT:
SUBMITTER: Kim HP
PROVIDER: S-EPMC2118651 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Kim Hyoung-Pyo HP Leonard Warren J WJ
The Journal of experimental medicine 20070625 7
Regulatory T cells (T reg cells) are a population of CD4+ T cells that limit immune responses. FoxP3 is a master control transcription factor for development and function of these cells, but its regulation is poorly understood. We have identified a T cell receptor-responsive enhancer in the FoxP3 first intron that is dependent on a cyclic-AMP response element binding protein (CREB)/activating transcription factor (ATF) site overlapping a CpG island. Methylation of this island inversely correlate ...[more]