Ontology highlight
ABSTRACT:
SUBMITTER: Kastenmuller W
PROVIDER: S-EPMC2118691 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Kastenmuller Wolfgang W Gasteiger Georg G Gronau Julian H JH Baier Robert R Ljapoci Ronny R Busch Dirk H DH Drexler Ingo I
The Journal of experimental medicine 20070820 9
CD8+ T cell responses directed against multiple pathogen-derived epitopes are characterized by defined immunodominance hierarchy patterns. A possible explanation for this phenomenon is that CD8+ T cells of different specificities compete for access to epitopes on antigen-presenting cells, and that the outcome of this so-called cross-competition reflects the number of induced T cells. In our study using a vaccinia virus infection model, we found that T cell cross-competition is highly relevant du ...[more]