Ontology highlight
ABSTRACT:
SUBMITTER: Simmer F
PROVIDER: S-EPMC212692 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Simmer Femke F Moorman Celine C van der Linden Alexander M AM Kuijk Ewart E van den Berghe Peter V E PV Kamath Ravi S RS Fraser Andrew G AG Ahringer Julie J Plasterk Ronald H A RH
PLoS biology 20031013 1
RNA-mediated interference (RNAi) is a method to inhibit gene function by introduction of double-stranded RNA (dsRNA). Recently, an RNAi library was constructed that consists of bacterial clones expressing dsRNA, corresponding to nearly 90% of the 19,427 predicted genes of C. elegans. Feeding of this RNAi library to the standard wild-type laboratory strain Bristol N2 detected phenotypes for approximately 10% of the corresponding genes. To increase the number of genes for which a loss-of-function ...[more]