Ontology highlight
ABSTRACT:
SUBMITTER: Nijtmans LG
PROVIDER: S-EPMC212747 | biostudies-literature | 2000 Jun
REPOSITORIES: biostudies-literature
Nijtmans L G LG de Jong L L Artal Sanz M M Coates P J PJ Berden J A JA Back J W JW Muijsers A O AO van der Spek H H Grivell L A LA
The EMBO journal 20000601 11
Prohibitins are ubiquitous, abundant and evolutionarily strongly conserved proteins that play a role in important cellular processes. Using blue native electrophoresis we have demonstrated that human prohibitin and Bap37 together form a large complex in the mitochondrial inner membrane. This complex is similar in size to the yeast complex formed by the homologues Phb1p and Phb2p. In yeast, levels of this complex are increased on co-overexpression of both Phb1p and Phb2p, suggesting that these tw ...[more]