Ontology highlight
ABSTRACT:
SUBMITTER: Salles-Passador I
PROVIDER: S-EPMC212794 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
Salles-Passador Isabelle I Munshi Anil A Cannella Dominique D Pennaneach Vincent V Koundrioukoff Stephane S Jaquinod Michel M Forest Eric E Podust Vladimir V Fotedar Arun A Fotedar Rati R
Nucleic acids research 20030901 17
Replication factor C (RF-C) complex binds to DNA primers and loads PCNA onto DNA, thereby increasing the processivity of DNA polymerases. We have previously identified a distinct region, domain B, in the large subunit of human RF-C (RF-Cp145) which binds to PCNA. We show here that the functional interaction of RF-Cp145 with PCNA is regulated by cdk-cyclin kinases. Phosphorylation of either RF-Cp145 as a part of the RF-C complex or RF-Cp145 domain B by cdk-cyclin kinases inhibits their ability to ...[more]