Ontology highlight
ABSTRACT:
SUBMITTER: Zimmerman JM
PROVIDER: S-EPMC212797 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
Zimmerman Jeff M JM Maher L James LJ
Nucleic acids research 20030901 17
'Indirect readout' refers to the proposal that proteins can recognize the intrinsic three-dimensional shape or flexibility of a DNA binding sequence apart from direct protein contact with DNA base pairs. The differing affinities of human papillomavirus (HPV) E2 proteins for different E2 binding sites have been proposed to reflect indirect readout. DNA bending has been observed in X-ray structures of E2 protein-DNA complexes. X-ray structures of three different E2 DNA binding sites revealed diffe ...[more]