Ontology highlight
ABSTRACT:
SUBMITTER: Gaubatz S
PROVIDER: S-EPMC21314 | biostudies-literature | 1998 Aug
REPOSITORIES: biostudies-literature
Gaubatz S S Wood J G JG Livingston D M DM
Proceedings of the National Academy of Sciences of the United States of America 19980801 16
E2F transcription factors play an important role in the regulation of cell cycle progression. We report here the cloning and characterization of an additional member of this family, E2F-6. E2F-6 lacks pocket protein binding and transactivation domains, and it is a potent transcriptional repressor that contains a modular repression domain at its carboxyl terminus. Overproduction of E2F-6 had no specific effect on cell cycle progression in asynchronously growing Saos2 and NIH 3T3 cells, but it inh ...[more]