Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses.
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ABSTRACT:
SUBMITTER: Birtwistle MR
PROVIDER: S-EPMC2132449 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses.
Birtwistle Marc R MR Hatakeyama Mariko M Yumoto Noriko N Ogunnaike Babatunde A BA Hoek Jan B JB Kholodenko Boris N BN
Molecular systems biology 20071113
Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers. To help understand ErbB signaling quantitatively, in this work we combine traditional experiments with computational modeling, building a model that describes how stimulation of all four ErbB receptors with epidermal growth factor (EGF) and heregulin (HRG) leads to activation of two critical downstream proteins, extracellular-signal-regulated kinase (ERK) and Akt. Model analysis and experimental validat ...[more]
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