Ontology highlight
ABSTRACT:
SUBMITTER: Nix RN
PROVIDER: S-EPMC2134957 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Nix Rebecca N RN Altschuler Sarah E SE Henson Peter M PM Detweiler Corrella S CS
PLoS pathogens 20071201 12
Salmonella enterica subspecies can establish persistent, systemic infections in mammals, including human typhoid fever. Persistent S. enterica disease is characterized by an initial acute infection that develops into an asymptomatic chronic infection. During both the acute and persistent stages, the bacteria generally reside within professional phagocytes, usually macrophages. It is unclear how salmonellae can survive within macrophages, cells that evolved, in part, to destroy pathogens. Evidenc ...[more]