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Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer.

ABSTRACT: Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide-major histocompatibility complex (pMHC) dimers to CD8-expressing T cells through nitration of tyrosines in a T-cell receptor (TCR)-CD8 complex. This process makes CD8-expressing T cells unable to bind pMHC and to respond to the specific peptide, although they retain their ability to respond to nonspecific stimulation. Nitration of TCR-CD8 is induced by MDSCs through hyperproduction of reactive oxygen species and peroxynitrite during direct cell-cell contact. Molecular modeling suggests specific sites of nitration that might affect the conformational flexibility of TCR-CD8 and its interaction with pMHC. These data identify a previously unknown mechanism of T-cell tolerance in cancer that is also pertinent to many pathological conditions associated with accumulation of MDSCs.

SUBMITTER: Nagaraj S 

PROVIDER: S-EPMC2135607 | biostudies-literature | 2007 Jul

REPOSITORIES: biostudies-literature

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Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer.

Nagaraj Srinivas S   Gupta Kapil K   Pisarev Vladimir V   Kinarsky Leo L   Sherman Simon S   Kang Loveleen L   Herber Donna L DL   Schneck Jonathan J   Gabrilovich Dmitry I DI  

Nature medicine 20070701 7

Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide-major histocompatibility complex (pMHC) dimers to CD8-expressing T cells through nitration of tyrosines in a T-cell receptor (TCR)-CD8 complex. This process makes CD8-expressing T cells unable to bind pMHC and to respond to the specific peptide, although they retai  ...[more]

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