Ontology highlight
ABSTRACT:
SUBMITTER: Kimura T
PROVIDER: S-EPMC2140104 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Kimura Tetsuya T Yamashita Shunji S Fukuda Tetsuya T Park Jun-Mi JM Murayama Miyuki M Mizoroki Tatsuya T Yoshiike Yuji Y Sahara Naruhiko N Takashima Akihiko A
The EMBO journal 20071115 24
To investigate how tau affects neuronal function during neurofibrillary tangle (NFT) formation, we examined the behavior, neural activity, and neuropathology of mice expressing wild-type human tau. Here, we demonstrate that aged (>20 months old) mice display impaired place learning and memory, even though they do not form NFTs or display neuronal loss. However, soluble hyperphosphorylated tau and synapse loss were found in the same regions. Mn-enhanced MRI showed that the activity of the parahip ...[more]