Ontology highlight
ABSTRACT:
SUBMITTER: Han J
PROVIDER: S-EPMC2140116 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Han Junhai J Reddig Keith K Li Hong-Sheng HS
The EMBO journal 20071122 24
Rapid deactivation of the Drosophila light receptor rhodopsin, through a visual arrestin Arr2 and a pathway that involves a transcription factor dCAMTA, is required for timely termination of light responses in the photoreceptor neuron. Here we report that this process is also critical for maintenance of the photoreceptor sensitivity. In both dCAMTA- and arr2-mutant flies, the endocytosis of the major rhodopsin Rh1 was dramatically increased, which was mediated by a G(q) protein that signals down ...[more]