Bim mediates mitochondria-regulated particulate matter-induced apoptosis in alveolar epithelial cells.
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ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC2140150 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
Bim mediates mitochondria-regulated particulate matter-induced apoptosis in alveolar epithelial cells.
Zhang J J Ghio A J AJ Chang W W Kamdar O O Rosen G D GD Upadhyay D D
FEBS letters 20070814 22
We studied the role of Bim, a pro-apoptotic BCL-2 family member in Airborne particulate matter (PM 2.5 microm)-induced apoptosis in alveolar epithelial cells (AEC). PM induced AEC apoptosis by causing significant reduction of mitochondrial membrane potential and increase in caspase-9, caspase-3 and PARP-1 activation. PM upregulated pro-apoptotic protein Bim and enhanced translocation of Bim to the mitochondria. ShRNABim blocked PM-induced apoptosis by preventing activation of the mitochondrial d ...[more]
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