Ontology highlight
ABSTRACT:
SUBMITTER: Maier LM
PROVIDER: S-EPMC2141824 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Maier Lisa M LM Anderson David E DE De Jager Philip L PL Wicker Linda S LS Hafler David A DA
Proceedings of the National Academy of Sciences of the United States of America 20071113 47
Little is known regarding the functional effects of common autoimmune susceptibility variants on human immune cells. The SNP CT60 (rs3087243; A/G) located in the 3' UTR of the CTLA4 gene has been associated with autoimmune diseases. We examined a cohort of healthy individuals stratified by genotypes at CTLA4 to gain insight into the functional effects of allelic variation on T cell signaling. Using phospho-site-specific mAbs, we tested the hypothesis that the CT60 genotype at CTLA4 is associated ...[more]