Ontology highlight
ABSTRACT:
SUBMITTER: Vasudevan G
PROVIDER: S-EPMC21429 | biostudies-literature | 1998 Aug
REPOSITORIES: biostudies-literature
Vasudevan G G Carter N S NS Drew M E ME Beverley S M SM Sanchez M A MA Seyfang A A Ullman B B Landfear S M SM
Proceedings of the National Academy of Sciences of the United States of America 19980801 17
All parasitic protozoa studied to date are incapable of purine biosynthesis and must therefore salvage purine nucleobases or nucleosides from their hosts. This salvage process is initiated by purine transporters on the parasite cell surface. We have used a mutant line (TUBA5) of Leishmania donovani that is deficient in adenosine/pyrimidine nucleoside transport activity (LdNT1) to clone genes encoding these nucleoside transporters by functional rescue. Two such genes, LdNT1.1 and LdNT1.2, have be ...[more]