Ontology highlight
ABSTRACT:
SUBMITTER: de la Rosa EJ
PROVIDER: S-EPMC21442 | biostudies-literature | 1998 Aug
REPOSITORIES: biostudies-literature
de la Rosa E J EJ Vega-Núñez E E Morales A V AV Serna J J Rubio E E de Pablo F F
Proceedings of the National Academy of Sciences of the United States of America 19980801 17
Insights have emerged concerning insulin function during development, from the finding that apoptosis during chicken embryo neurulation is prevented by prepancreatic (pro)insulin. While characterizing the molecules involved in this survival effect of insulin, we found insulin-dependent regulation of the molecular chaperone heat shock cognate 70 kDa (Hsc70), whose cloning in chicken is reported here. This chaperone, generally considered constitutively expressed, showed regulation of its mRNA and ...[more]