Ontology highlight
ABSTRACT:
SUBMITTER: Singer-Lahat D
PROVIDER: S-EPMC2148073 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Singer-Lahat Dafna D Chikvashvili Dodo D Lotan Ilana I
PloS one 20080102 1
K(+) efflux through voltage-gated K(+) (Kv) channels can attenuate the release of neurotransmitters, neuropeptides and hormones by hyperpolarizing the membrane potential and attenuating Ca(2+) influx. Notably, direct interaction between Kv2.1 channels overexpressed in PC12 cells and syntaxin has recently been shown to facilitate dense core vesicle (DCV)-mediated release. Here, we focus on endogenous Kv2.1 channels and show that disruption of their interaction with native syntaxin after ATP-depen ...[more]