Ontology highlight
ABSTRACT:
SUBMITTER: Maney T
PROVIDER: S-EPMC2148171 | biostudies-literature | 1998 Aug
REPOSITORIES: biostudies-literature
Maney T T Hunter A W AW Wagenbach M M Wordeman L L
The Journal of cell biology 19980801 3
Mitotic centromere-associated kinesin (MCAK) is recruited to the centromere at prophase and remains centromere associated until after telophase. MCAK is a homodimer that is encoded by a single gene and has no associated subunits. A motorless version of MCAK that binds centromeres but not microtubules disrupts chromosome segregation during anaphase. Antisense-induced depletion of MCAK results in the same defect. MCAK overexpression induces centromere-independent bundling and eventual loss of spin ...[more]