Ontology highlight
ABSTRACT:
SUBMITTER: Forester CM
PROVIDER: S-EPMC2148389 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Forester Craig M CM Maddox Jessica J Louis Justin V JV Goris Jozef J Virshup David M DM
Proceedings of the National Academy of Sciences of the United States of America 20071204 50
Inactivation of maturation-promoting factor [(MPF) Cdk1/Cyclin B] is a key event in the exit from mitosis. Although degradation of Cyclin B is important for MPF inactivation, recent studies indicate that Cdk1 phosphorylation and inactivation occur before Cyclin B degradation and, therefore, also may be important steps in the exit from mitosis. Cdk1 activity is controlled by the Cdc25C phosphatase, which is turned on at the G(2)/M transition to catalyze Cdk1 activation. PP2A:B56delta is a negativ ...[more]