Ontology highlight
ABSTRACT:
SUBMITTER: Yuan L
PROVIDER: S-EPMC2149905 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Yuan Liya L Kawada Mariko M Havlioglu Necat N Tang Hao H Wu Jane Y JY
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050101 3
Mutations in human PRPF31 gene have been identified in patients with autosomal dominant retinitis pigmentosa (adRP). To begin to understand mechanisms by which defects in this general splicing factor cause retinal degeneration, we examined the relationship between PRPF31 and pre-mRNA splicing of photoreceptor-specific genes. We used a specific anti-PRPF31 antibody to immunoprecipitate splicing complexes from retinal cells and identified the transcript of rhodopsin gene (RHO) among RNA species as ...[more]