Ontology highlight
ABSTRACT:
SUBMITTER: Beckloff N
PROVIDER: S-EPMC2151458 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Beckloff Nicholas N Laube Danielle D Castro Tammy T Furgang David D Park Steven S Perlin David D Clements Dylan D Tang Haizhong H Scott Richard W RW Tew Gregory N GN Diamond Gill G
Antimicrobial agents and chemotherapy 20070904 11
Antimicrobial peptides (AMPs) are naturally occurring, broad-spectrum antimicrobial agents that have recently been examined for their utility as therapeutic antibiotics. Unfortunately, they are expensive to produce and are often sensitive to protease digestion. To address this problem, we have examined the activity of a peptide mimetic whose design was based on the structure of magainin, exhibiting its amphiphilic structure. We demonstrate that this compound, meta-phenylene ethynylene (mPE), exh ...[more]