DNA combing reveals intrinsic temporal disorder in the replication of yeast chromosome VI.
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ABSTRACT:
SUBMITTER: Czajkowsky DM
PROVIDER: S-EPMC2151843 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Publications
DNA combing reveals intrinsic temporal disorder in the replication of yeast chromosome VI.
Czajkowsky Daniel M DM Liu Jie J Hamlin Joyce L JL Shao Zhifeng Z
Journal of molecular biology 20071023 1
It is generally believed that DNA replication in most eukaryotes proceeds according to a precise program in which there is a defined temporal order by which each chromosomal region is duplicated. However, the regularity of this program at the level of individual chromosomes, in terms of both the relative timing and the size of the DNA domain, has not been addressed. Here, the replication of chromosome VI from synchronized budding yeast was studied at a resolution of approximately 1 kb with DNA c ...[more]
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