Ontology highlight
ABSTRACT:
SUBMITTER: Serulle Y
PROVIDER: S-EPMC2153457 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Serulle Yafell Y Zhang Shuang S Ninan Ipe I Puzzo Daniela D McCarthy Maria M Khatri Latika L Arancio Ottavio O Ziff Edward B EB
Neuron 20071101 4
Trafficking of AMPA receptors (AMPARs) is regulated by specific interactions of the subunit intracellular C-terminal domains (CTDs) with other proteins, but the mechanisms involved in this process are still unclear. We have found that the GluR1 CTD binds to cGMP-dependent protein kinase II (cGKII) adjacent to the kinase catalytic site. Binding of GluR1 is increased when cGKII is activated by cGMP. cGKII and GluR1 form a complex in the brain, and cGKII in this complex phosphorylates GluR1 at S845 ...[more]