Ontology highlight
ABSTRACT:
SUBMITTER: Brandler S
PROVIDER: S-EPMC2154386 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Brandler Samantha S Lucas-Hourani Marianne M Moris Arnaud A Frenkiel Marie-Pascale MP Combredet Chantal C Février Michèle M Bedouelle Hugues H Schwartz Olivier O Desprès Philippe P Tangy Frédéric F
PLoS neglected tropical diseases 20071212 3
Dengue disease is an increasing global health problem that threatens one-third of the world's population. Despite decades of efforts, no licensed vaccine against dengue is available. With the aim to develop an affordable vaccine that could be used in young populations living in tropical areas, we evaluated a new strategy based on the expression of a minimal dengue antigen by a vector derived from pediatric live-attenuated Schwarz measles vaccine (MV). As a proof-of-concept, we inserted into the ...[more]