Ontology highlight
ABSTRACT:
SUBMITTER: Ohgami RS
PROVIDER: S-EPMC2156108 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Nature genetics 20051016 11
The reduction of iron is an essential step in the transferrin (Tf) cycle, which is the dominant pathway for iron uptake by red blood cell precursors. A deficiency in iron acquisition by red blood cells leads to hypochromic, microcytic anemia. Using a positional cloning strategy, we identified a gene, six-transmembrane epithelial antigen of the prostate 3 (Steap3), responsible for the iron deficiency anemia in the mouse mutant nm1054. Steap3 is expressed highly in hematopoietic tissues, colocaliz ...[more]